[ comparative study on the personality traits of opioid- dependents with and without somatic chronic pain complaints]

Some people use opioid substances to relief their chronic somatic pains. There are differences in the personality traits of this individuals and others who abuse opioid substances. The purpose of the present study was to compare these two groups in regard to their personality traits and disorders. In a cross-sectional study between 2007 to 2011, all patients referred for drug quit to the outpatient addiction clinic of Imam Hospital affiliated to Jundishapur University were investigated demographically. In addition, all of them underwent physical examination, MMPI test and psychiatric interview. Then they were divided into two groups of "with pain complaint" and "without pain complaint". Their personality traits were compared using t-test and chi[2]. The total number of patients was 488, including 478 males and 10 females. Mean scores of Psychatenia [pt] and paranoia [Pa] indexes in the patients who suffered from chronic non- cancer pain was lower in comparison to the patients without pain complaint. Based on the results of psychological interview, the prevalence of personality disorder was higher in the "without pain" group. Patients with chronic pain had higher educational degrees and they were more likely under the influence of their friends at the onset of opioid abuse. In the present study those who used opioid for pain relief, had healthier psychiatric profiles and personalities. Their psychiatric interviews were more valid and reliable and their psychological problems were less than the other group and their addiction was a maladaptive behavior

Evaluation of vitamin b-complex efficacy add on citalopram in outpatient with major depressive disorder

Major depression disorder [MDD] is most common psychiatric disorder in community. MDD is one of the important disorders because of its prevalence and serious complication such as suicide, substance abuse, loss of well being and function, this study was investigated to determine the efficacy of vitamin B- complex add on citalopram, [its cofactor role in serotonin synthesis] in treatment of MDD. This study is a double-blinded placebo-control cinical trial on 40 MDD patients [18-45 years old] referred to psychiatric clinic in 2009. Duration of study was 6 weeks. Depressive symptoms were assessed with Beck Depression Inventory at 0, 3 and 6 weeks after intervention. Data was analized by using SPSS, ANOVA, Chi- square and Fisher tests. In both groups [B-complex and placebo], symptoms were significantly improved at the end of study respectively [P=0.002, P=0.04]. Beck's rating scale score between two groups was not significantly different [P=0.99]. The main finding of this study was that efficacy of either vitamin B-complex on citalopram or citalopram alone was not differed in reduction of depression symptoms. Because of low sample size, short duration of study and basic effect of vitamins in behavior, further future works to be considered